Chapter
35.
Hypertension: complications and therapy
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Keypoints
- In the kidney, hypertension initially causes proteinuria then glomerulosclerosis
- In the heart it causes atherosclerosis and left ventricular hypertrophy
- If grade 3 or 4 retinopathy is present (haemorrhages, exudates or papilledema),
the hypertension is potentially dangerous and requires close supervision
and control
- In black patients, calcium channel blockers, alpha 1 adrenergic blockers
and diuretics are useful
- In diabetics, angiotensin converting enzyme inhibitors may be beneficial
and effective. Beta blockers may blunt the awareness of hypoglycemia and
worsen symptoms of peripheral vascular disease
- Alpha 1 antagonists may improve urine flow rates in men with prostatic
hypertorphy.
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Endothelin antagonists
Benigni A, Remuzzi G, 1999
Lancet 353: 133-138
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