• There are many causes of tubulo-interstital nephritis as most causes of renal tissue damage can cause tubulo-interstitial damage.
• Tubulo-interstitial nephritis is often just termed interstitial nephritis.
• Major causes of acute interstitial nephritis include the drug groups: analgesics, epecially non-steroidal anti-inflammatory drugs, diuretics and antibiotics.
• A major complication of chronic disease is papillary necrosis and disordered tubular function, especially the ability to concentrate urine.

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C. A. O'Callaghan 2004