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Chapter 31. Specific disease affecting the glomeruli
Previous Chapter Next Chapter Self-Assessment for this chapter
Keypoints
- Antibodies to glomerular basement membranes (AGBM) occur in Goodpasture's disease
- Antibodies to neutrophil cytoplasmic contents (ANCA) occur in primary systemic vasculitis
- p-ANCA against myeloperoxidase occurs in microscopic polyangiitis
- c-ANCA against proteinase 3 occurs in Wegener's granulomatosis.
- In systemic lupus erythematosus, there are antibodies to dsDNA, complement levels are low, the ESR is high and the CRP is low.
- Hepatitis C causes cryoglobulinemia and mesangiocapillary glomerulonephritis.
- Myeloma can cause cast nephropathy, light chain deposition disease and amyloidosis.
- Amyloidosis can arise in chronic inflammation (AA amyloid) or if there is excess immunoglobulin in the form of a paraprotein (AL amyloid)
- Gold and penicillamine cause membranous nephropathy.
- Alport's disease is an X linked mutation in the alpha 3 chain of collagen type IV and causes renal disease and deafness.
Self-Assessment Questions for this Chapter