Chapter
17.
Regulation of body sodium and body water
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Keypoints
- Body osmolality is controlled by regulating body water content
- Body volume is controlled by regulating body sodium content
- Body water content is altered by changes in thirst and renal water excretion
- Body sodium content is altered by changes in renal sodium excretion
- Body osmolality is detected by osmoreceptors in the hypothalamus
- Body volume is detected by stretch receptors mainly in the circulation
- Osmoreceptors influence ADH release ADH enhances renal water reabsorption
- Many factors influence renal sodium excretion, especially the renin-angiotensin
II-aldosterone system which promotes sodium reabsorption
- Osmolality will usually be regulated even if this means that body volume
will be altered from normal.
- The main exceptions to this rule arise if the regulatory mechanisms
are themselves disordered
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Natriuretic peptides
Levin ER, Gardner DG, Samson WK 1998
N Engl J Med 339 321-328
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