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Chapter 15. Renal pharmacology: diuretics
Previous Chapter Next Chapter Self-Assessment for this chapter
Keypoints
- Diuretics reduce water reabsorption and increase urine volume
- Loop diuretics such as furosemide (frusemide) inhibit the NaK2Cl cotransporter in the loop of Henle
- Thiazide diuretics inhibit the NaCl cotransporter in the distal tubule
- Amiloride inhibits the ENac epithelial sodium channel in the collecting duct
- Spironolactone is an aldosterone antagonist
- Mannitol is an osmotic diuretic
- Acetazolamide inhibits carbonic anhydrase Try to remember these points
- Of the commonly used diuretics, loop diuretics and thiazide diuretics increase potassium excretion, whereas amiloride and spironolactone reduce potassium excretion
Self-Assessment Questions for this Chapter